Studies on Cadiotonic Agents. IV. : Sunthesis of Novel 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Substituted Hydantoin and 2-Thiohydantoin Rings
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概要
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A series of novel 1-(6,7-dimethoxy-4-quinazolinyl)piperidines carrying substituted hydantoin and 2-thiohydantoin rings was synthesized and examined for cardiotonic activity in anesthetized dogs. Introduction of isopropyl and sec-butyl group at the 5-position of the hydantoin and thiohydantoin rings led to potent inotropic activity. Effects of insertion of an alkyl chain between the piperidine and the hydantoin rings were also examined. The structural requirements necessary for optimal cardiotonic activity within the series were investigated.
- 社団法人日本薬学会の論文
- 1990-11-25
著者
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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平田 正
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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大野 哲司
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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野本 裕二
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
-
久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
野本 裕二
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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