Synthesis of 2-Amino-2-deoxy-β-D-arabinofuranosyl Nucleosides

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概要

• 論文の詳細を見る

• 9-(2-Deoxy-2-amino-β-D-arabinofuranosyl) adenine (IIIa) and guanine (IIIb) were synthesized from the corresponding azide compounds (II) obtained by nucleophilic substitution of tosyloxy groups of 2'-O-p-toluensulfonyladenosine (Ia) and guanosine (Ib), respectively. Their antitumor activity against sarcoma-180 solid tumor and cytotoxic activity against HeLa-S_3 cells were determined.

• 社団法人日本薬学会の論文
• 1979-03-25

著者

• 今井 良二

  Fuji Medical Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

• 平田 正

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 佐藤 章

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

• 佐藤 章

  Tokyo Research Laboratory

• 中溝 喜博

  Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

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