Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
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概要
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A series of 1-and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine (26) (KF5908) seemed the most promising.
- 社団法人日本薬学会の論文
- 1985-03-25
著者
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粕谷 豊
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
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小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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粕谷 豊
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University
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粕谷 豊
Faculty of Pharmaceutical Sciences, University of Tokyo
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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周藤 勝一
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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重信 弘毅
Faculty of Pharmaceutical Sciences, Univerisity of Tokyo
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階上 万規子
Faculty of Pharmaceutical Sciences, University of Tokyo
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辛島 直子
Faculty of Pharmaceutical Sciences, University of Tokyo
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重信 弘毅
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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中溝 喜博
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
周藤 勝一
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
中溝 喜博
Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
-
高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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辛島 直子
Faculty Of Pharmaceutical Sciences University Of Tokyo
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階上 万規子
Faculty Of Pharmaceutical Sciences University Of Tokyo
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