Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
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概要
- 論文の詳細を見る
A series of 1-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-imidazolidinone and 2-imidazolidinethione derivatives was synthesized and examined for cardiotonic activity in anesthetized dogs. Alkylation of the 2-imidazolidinone (1) afforded the N-alkylated products, while alkylation of the 2-imidazolidinethione (12) afforded the S-alkylated derivatives accompanied with a small quantity of the N-alkylated products. The N-alkylated derivatives showed generally potent activity, and the S-alkylated ones exhibited weak activity. Insertion of an alkyl group between the piperidine and the imidazolidinone moiety generally resulted in a fall in activity.
- 社団法人日本薬学会の論文
- 1990-09-25
著者
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小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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平田 正
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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大野 哲司
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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野本 裕二
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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中村 譲治
Pharmaceutical Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
-
久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
中村 譲治
Pharmaceutical Research Laboratory Fuji Kyowa Hakko Kogyo Co. Ltd.
-
野本 裕二
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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