Synthesis of a Dibenz[b, e]oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679 ((Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2-acetic Acid Hydrochloride)

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概要

• 論文の詳細を見る

• (Z)-11-[3-(Dimethlamino)propylidene]-2-(methoxycarbonyl)methyl-6,11-dihydrodibenz[b, e]oxepin-9-acrylic acid (5) was prepared for application to the radiommunoassay of KW-4679 (1,(Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2-acetic acid hydrochloride). The acrylic acid moiety in the 9-position of 5 was employed for coupling with an amino group of bovine serum albumin (BSA) to provide 17. Subsequently, the conjugate 17 was treated with aquenus NaOH to hydrolyze the terminal methoxycarbonyl group in the 2-position of the BSA conjugated 5. Antiserum raised against the antigenic BSA-conjugate 4 finally obtained was specific for 1.

• 社団法人日本薬学会の論文
• 1992-09-25

著者

• 佐藤 秀幸

  Pharmaceutical Resarch Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 小林 智

  協和発酵工業株式会社 医薬開発本部非臨床開発部

• 桑原 隆

  協和発酵工業(株)医薬研究所

• 内村 達雄

  協和発酵工業 医薬研究所

• 大島 悦男

  Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 小場瀬 宏之

  Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 内村 達雄

  Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 桑原 隆

  Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 小林 智

  Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 小場瀬 宏之

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 大島 悦男

  協和発酵工業(株)医薬研究センター

• Katagiri S

  Faculty Of Engineering Niigata University

• Kobayashi Satoshi

  Analytical & Pharmacokinetic Laboratories Pharmaceutical Research Institute Kyowa Hakko Hagyo Co

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