Synthesis of 1'-Substituted 2-Amino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] Derivatives
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概要
- 論文の詳細を見る
In the cyclization reaction of 4-hydroxy-4-[2-(N-substituted carbamol)aminophenyl]piperidine derivatives (3) by treatment with acid, 2-amino-spiro[4H-3,1-benzoxazine-4,4-piperidine] derivatives (4) were obtained. One of the products, 2-methylamino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] (4g), was converted to 1-(2-hydroxy-2-phenethyl)-2-methylamino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] derivatives (12), which are our target compounds for pharmacological screening tests on antihypertensive activity. However, these compounds did not show any remarkable antihypertensive activity.
- 公益社団法人日本薬学会の論文
- 1988-12-25
著者
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小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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