Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents
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概要
- 論文の詳細を見る
A series of piperidine derivatives with a 2-oxo-1,2,3,4-tetrahydro-quinazoline or 2,4-dioxo-1,2,3,4-tetrahydroquinazoline ring at the 4-position were prepared and tested for antihypertensive activity. Among the compounds tested, 1-[2-hydroxy-2-(3,4-methylenedioxyphenyl)ethyl]-4-(2,4-dioxo-1,2,3,4-tetrahydro-3-quinazolinyl)piperidine (20) and 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(2-oxo-1,2,3,4-tetrahydro-3-quinazolinylmethyl)piperidine (30) produced relatively strong hypotension in the spontaneously hypertensive rat model.
- 社団法人日本薬学会の論文
- 1986-05-25
著者
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粕谷 豊
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
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小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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粕谷 豊
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University
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唐沢 啓
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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粕谷 豊
Faculty of Pharmaceutical Sciences, University of Tokyo
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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唐沢 啓
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
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周藤 勝一
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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重信 弘毅
Faculty of Pharmaceutical Sciences, Univerisity of Tokyo
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重信 弘毅
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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周藤 勝一
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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