New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones
スポンサーリンク
概要
- 論文の詳細を見る
As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only moderate antihypertensive activity in three hypertensive rat models.
- 公益社団法人日本薬学会の論文
- 1982-02-25
著者
-
小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
-
寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
高井 春樹
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,
-
周藤 勝一
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
-
重信 弘毅
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
-
中溝 喜博
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
-
高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
-
久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
久保 和博
Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical Research Laboratories
-
周藤 勝一
Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical Research Laboratories
-
柏谷 豊
Fuji, Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo
-
柏谷 豊
Fuji Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo
-
重信 弘毅
Fuji Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo
-
小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
柏谷 豊
Fuji Kyowa Hakko Kogyo Co. Ltd. Faculty Of Pharmaceutical Sciences University Of Tokyo
-
周藤 勝一
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
中溝 喜博
Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
-
高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
関連論文
- Synthesis and Adrenergic β-Blocking Activity of Some Propanolamine Derivatives
- Synthesis of a Dibenz[b, e]oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679 ((Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2-acetic Acid Hydrochloride)
- 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. II. Synthesis and Antianginal Activity of Aryl- or Arylcarbonylpiperazine Derivatives
- Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats
- Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents
- Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity
- Infusion Rate-Dependent Positive Inotropic Action of Ouabain in Rabbits(Pharmaceutical)
- Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
- New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position
- The Actions of N-Propyl Ajmaline on Experimental Arrhythmias and Electrophysiological Properties of the Heart
- 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. I. Synthesis and Antianginal Activity of Alkylpiperazine Derivatives
- Effects of N-acetyl-L-cysteine on Teratogenicity of Cadmium in Mice
- Studies on Cardiotonic Agents. V. Synthesis of 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Various 5-Membered Heterocyclic Rings at the 4-Position
- Studies on Cadiotonic Agents. IV. : Sunthesis of Novel 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Substituted Hydantoin and 2-Thiohydantoin Rings
- Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
- Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives
- Synthesis of 2-Amino-2-deoxy-β-D-arabinofuranosyl Nucleosides
- Synthesis of Purine Nucleoside Nitrosoureas and Their Antitumor Activities
- A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6,11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives
- A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6,11-dihydrodibenz[b, e]oxepin Derivatives
- 37. N-置換フェニルカルバモイルアミノ酸誘導体の除草活性。
- 36. アリールチオー及びアラルキルチオーカルボニルアミノ酸誘導体の除草活性
- New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives
- Potentiating Effects of Bradykinin-related Substances on Bradykinin-induced Contraction of Guinea Pig Ileum and Hypotension in Rats
- Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1,2,3-Benzotriazine Derivatives
- Synthesis of 1'-Substituted 2-Amino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] Derivatives
- Cyclofunctionalization of Olefinic Urethanes and Ureas with Halogens. : Synthesis of 1-Substituted Spiro[piperidine-4,4'(3'H)-quinazolin]-2'(1'H)-one Derivatives
- Reaction of Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one Derivatives and Related Compounds with Phosphorus Oxychloride
- Synthesis and Pharmacological Evaluation of Piperidine Derivatives with Various Heterocyclic Rings at the 4-Position
- New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones
- 2,2'-Dithiodibenzamides as Inhibitors of Blood Platelet Aggregation
- Studies on Cardiotonic Agents. VII. Potent Cardiotonic Agent KF15232 with Myofibrillar Ca^ Sensitizing Effect
- Studies on Cardiotonic Agents. VI. Synthesis of Novel 4,5-Dihydro-3(2H)-pyridazinone Derivatives Carrying Some Benzoheterocycles at the 6-Position
- Reaction of 11-Methoxy-6,11-dihydrodibenz[b, e]oxepins with Active Methylene Compounds
- Synthetic Inhibitors of Enzymes involved in Peptidoglycan Biosynthesis. I. Preparation of D-Alanine Chloromethylketones
- Flunarizineの脳血流量および脳酸素消費量に及ぼす作用について
- (E)-1-[Bis-(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride(flunarizine)の脳循環に対する作用について