Synthesis of Purine Nucleoside Nitrosoureas and Their Antitumor Activities

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概要

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• Guanine and xanthine nucleoside derivatives (3,4 and 6) bearing nitrosourea functional groups were synthesized from guanine nucleoside ureas (2) obtained by the reaction of 2'-deoxy-2'-aminoguanosine (1) with isocyanates and their antitumor activity against sarcoma-180 solid tumor and leukemia L-1210 were determined. Among the compounds tested, 2'-deoxy-2'-[3-(2-chloroethyl)-3-nitrosoureido]-xanthosine (4b) found to have the most potent activity. Moreover, very slight decrease in white blood cells of mice bearing sarcoma-180 solid tumor was observed after administration of 4b.

• 社団法人日本薬学会の論文
• 1979-03-25

著者

• 今井 良二

  Fuji Medical Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

• 平田 正

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 佐藤 章

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

• 佐藤 章

  Tokyo Research Laboratory

• 中溝 喜博

  Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

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