Studies on Cardiotonic Agents. V. Synthesis of 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Various 5-Membered Heterocyclic Rings at the 4-Position
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概要
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A series of 1-(6,7-dimethoxy-4-quinazolinyl)piperidines carrying various 5-membered heterocycles at the 4-position was synthesized and examined for cardiotonic activity in anesthesized dogs. The (4-oxo-2-thioxo-3-imidazolidinyl)amino derivatives showed the most potent inotropic activity. Marked loss of activity was observed in the 2,4-dihydro-3-thioxo-3H-1,2,4-triazolyl, the 2,4-dihydro-3-oxo-3H-pyrazolyl and the (2,3-dihydro-2-thioxo-3H-1,3,4-thiadiazol-5-yl)amino derivatives. The synthesis and structure-activity relationships are discussed.
- 社団法人日本薬学会の論文
- 1991-01-25
著者
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寺西 正行
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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平田 正
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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大野 哲司
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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