Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity

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概要

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• General synthetic methods for the preparation of 4-(2-aminophenyl)-4-hydroxypiperidine derivatives have been developed. The application use of these derivatives in the synthesis of 1'-substituted spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one derivatives is described, and the antihypertensive activity of the products is also reported.

• 社団法人日本薬学会の論文
• 1985-03-25

著者

• 粕谷 豊

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University

• 小場瀬 宏之

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.

• 寺西 正行

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 粕谷 豊

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University

• 唐沢 啓

  Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 粕谷 豊

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 久保 和博

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 唐沢 啓

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 高井 春樹

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,

• 周藤 勝一

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 重信 弘毅

  Faculty of Pharmaceutical Sciences, Univerisity of Tokyo

• 階上 万規子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 辛島 直子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 重信 弘毅

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo

• 高井 春樹

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 久保 和博

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 小場瀬 宏之

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 周藤 勝一

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 高井 春樹

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 辛島 直子

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 階上 万規子

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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