Reaction of 11-Methoxy-6,11-dihydrodibenz[b, e]oxepins with Active Methylene Compounds
スポンサーリンク
概要
- 論文の詳細を見る
A new method for effecting the formation of a carbon-carbon single bond at the 11-position of 6,11-dihydrodibenz[b, e]oxepins was developed. The reaction of 11-methoxydibenz[b, e]oxepins with active methylene compounds proceeded in the presence of TiCl_4 under mild conditions to afford the correponding 11-substituted dibenzoxepins in moderate to excellent yield. This was considered to be a vinylogous reaction of ketals with active methylene compounds. The efficacy and some applications of this method are described.
- 公益社団法人日本薬学会の論文
- 1993-01-15
著者
-
大島 悦男
Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
小場瀬 宏之
Pharmaceutical Resarch Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
熊沢 利昭
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
大島 悦男
協和発酵工業(株)医薬研究センター
-
熊沢 利昭
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
関連論文
- Synthesis and Adrenergic β-Blocking Activity of Some Propanolamine Derivatives
- Synthesis of a Dibenz[b, e]oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679 ((Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2-acetic Acid Hydrochloride)
- アレルギー疾患治療薬の開発状況
- Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents
- Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity
- Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
- New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position
- Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
- Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives
- A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6,11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives
- A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6,11-dihydrodibenz[b, e]oxepin Derivatives
- New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives
- Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1,2,3-Benzotriazine Derivatives
- Synthesis of 1'-Substituted 2-Amino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] Derivatives
- Cyclofunctionalization of Olefinic Urethanes and Ureas with Halogens. : Synthesis of 1-Substituted Spiro[piperidine-4,4'(3'H)-quinazolin]-2'(1'H)-one Derivatives
- Reaction of Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one Derivatives and Related Compounds with Phosphorus Oxychloride
- Synthesis and Pharmacological Evaluation of Piperidine Derivatives with Various Heterocyclic Rings at the 4-Position
- New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones
- Reaction of 11-Methoxy-6,11-dihydrodibenz[b, e]oxepins with Active Methylene Compounds
- 抗アレルギー薬オロパタジン塩酸塩の創製