New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives

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概要

• 論文の詳細を見る

• A series of 4-piperidylbenzimidazolinones, of formula I, has been synthesized. Selective syntheses of erythro and threo isomers of α-alkyl phenylethanolamines were investigated. Most members of the series have been shown to have antihypertensive effects in various animal models. Compounds 27 and 31 (threo isomers) showed the strongest hypotensive activities in the present screening series.

• 公益社団法人日本薬学会の論文
• 1982-02-25

著者

• 小場瀬 宏之

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.

• 寺西 正行

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 栗原 順一

  帝京大学薬学部

• 栗原 順一

  帝京大学 医学部内科

• 栗原 順一

  日本医科大学 第2内科

• 久保 和博

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 高井 春樹

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,

• 周藤 勝一

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 加藤 仁

  帝京大学薬学部、薬理学教室

• 重信 弘毅

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo

• 中溝 喜博

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.

• 高井 春樹

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 久保 和博

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 久保 和博

  Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical Research Laboratories

• 周藤 勝一

  Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical Research Laboratories

• 柏谷 豊

  Fuji, Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo

• 加藤 仁

  Fuji, Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo

• 重信 弘毅

  Fuji, Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo

• 栗原 順一

  Fuji, Kyowa Hakko Kogyo Co., Ltd. Faculty of Pharmaceutical Sciences, University of Tokyo

• 栗原 順一

  帝京大学薬学部薬理学教室

• 小場瀬 宏之

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 柏谷 豊

  Fuji Kyowa Hakko Kogyo Co. Ltd. Faculty Of Pharmaceutical Sciences University Of Tokyo

• 周藤 勝一

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 中溝 喜博

  Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

• 高井 春樹

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

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