Synthesis and Adrenergic β-Blocking Activity of Some Propanolamine Derivatives
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概要
- 論文の詳細を見る
Some propanolamine derivatives were synthesized and their β-adrenergic blocking activities were determined. Among the compounds tested, all compounds with benzothiazole nucleus were found to have potent β-adrenergic blocking activity, and those with other nuclei failed to produce substantial β-blocking activity with one exception. Three compounds with benzothiazole nucleus were more potent than sotalol in their β-blocking activity, and the other two were equipotent to sotalol. One with benzotriazole nucleus had about the same β-blocking activity as sotalol.
- 社団法人日本薬学会の論文
- 1978-05-25
著者
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粕谷 豊
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
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小場瀬 宏之
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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矢田 精一
Sakai Factory, Kyowa Hakko Kogyo Co., Ltd.
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粕谷 豊
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University
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重信 弘毅
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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小場瀬 宏之
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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矢田 精一
Sakai Factory Kyowa Hakko Kogyo Co. Ltd.
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