Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1,2,3-Benzotriazine Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

• 公益社団法人日本薬学会の論文
• 1990-08-25

著者

• 小場瀬 宏之

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.

• 寺西 正行

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 久保 和博

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 高井 春樹

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,

• 野本 裕二

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 高井 春樹

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 野本 裕二

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,

• 中村 譲治

  Pharmaceutical Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.,

• 久保 和博

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 小場瀬 宏之

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 中村 譲治

  Pharmaceutical Research Laboratory Fuji Kyowa Hakko Kogyo Co. Ltd.

• 野本 裕二

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 高井 春樹

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Synthesis and Adrenergic β-Blocking Activity of Some Propanolamine Derivatives
• Synthesis of a Dibenz[b, e]oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679 ((Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2-acetic Acid Hydrochloride)
• 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. II. Synthesis and Antianginal Activity of Aryl- or Arylcarbonylpiperazine Derivatives
• Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats
• Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents
• Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity
• Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
• New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position
• 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. I. Synthesis and Antianginal Activity of Alkylpiperazine Derivatives
• Studies on Cardiotonic Agents. V. Synthesis of 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Various 5-Membered Heterocyclic Rings at the 4-Position
• Studies on Cadiotonic Agents. IV. : Sunthesis of Novel 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Substituted Hydantoin and 2-Thiohydantoin Rings
• Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
• Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives
• A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6,11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives
• A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6,11-dihydrodibenz[b, e]oxepin Derivatives
• 37. N-置換フェニルカルバモイルアミノ酸誘導体の除草活性。
• 36. アリールチオー及びアラルキルチオーカルボニルアミノ酸誘導体の除草活性
• New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives
• Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1,2,3-Benzotriazine Derivatives
• Synthesis of 1'-Substituted 2-Amino-spiro[4H-3,1-benzoxazine-4,4'-piperidine] Derivatives
• Cyclofunctionalization of Olefinic Urethanes and Ureas with Halogens. : Synthesis of 1-Substituted Spiro[piperidine-4,4'(3'H)-quinazolin]-2'(1'H)-one Derivatives
• Reaction of Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one Derivatives and Related Compounds with Phosphorus Oxychloride
• Synthesis and Pharmacological Evaluation of Piperidine Derivatives with Various Heterocyclic Rings at the 4-Position
• New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones
• 2,2'-Dithiodibenzamides as Inhibitors of Blood Platelet Aggregation
• Studies on Cardiotonic Agents. VII. Potent Cardiotonic Agent KF15232 with Myofibrillar Ca^ Sensitizing Effect
• Studies on Cardiotonic Agents. VI. Synthesis of Novel 4,5-Dihydro-3(2H)-pyridazinone Derivatives Carrying Some Benzoheterocycles at the 6-Position
• Reaction of 11-Methoxy-6,11-dihydrodibenz[b, e]oxepins with Active Methylene Compounds
• Synthesis of 8-Alkyladenosines, 8,2'-Anhydro-8-hydroxymethyl-9-(β-D-arabinofuranosyl) adenine and Related Compounds (Nucleosides and Nucleotides. LVIII)
• Flunarizineの脳血流量および脳酸素消費量に及ぼす作用について
• (E)-1-[Bis-(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride(flunarizine)の脳循環に対する作用について
• Synthesis of 2- and 8-Cyanoadenosines and Their Derivatives : Nucleosides and Nucleotides. XXVII

もっと見る 閉じる

スポンサーリンク