Flunarizineの脳血流量および脳酸素消費量に及ぼす作用について
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概要
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flunarizineの脳血流量および脳酸素消費量に及ぼす作用をvenous outflow法を用いて，pancronium不動化犬でpapaverineと比較検討した．1)flunarizine(0.3，1mg/kg，i.v.)およびpapaverine(1mg/kg，i.v.)の投与により脳血流量は増加し，脳血管抵抗は低下した．同時に血圧下降および脳脊髄圧の上昇もみられ，これらの作用の持続性はflunarizine>papaverineの順であった．2)心拍数はpapaverineにより著明な増加を，一方flunarizineでは1mg/kg，i.v.の投与量において有意な減少を示した．中心静脈圧はpapaverineにより影響が認められなかったが，flunarizineでは0.3，1mg/kg，i.v.のいずれの用量でも軽度，一過性の上昇を示した．3)脳動静脈酸素較差はflunarizine 0.3mg/kg，i.v.投与では有意な変化が認められなかったが，同薬物の1mg/kg，i.v.およびpapaverine 1mg/kg，i.v.により有意な減少を示した．一方，脳酸素消費量はflunarizineおよびpapaverineのいずれでも影響が認められなかった．4)血液ガス組成に対して，flunarizine(0.3，1mg/kg，i.v.)およびpapaverine(1mg/kg，i.v.)は脳静脈血酸素分圧を上昇させ，flunarizineの1mg/kg，i.v.投与は軽度，一過性ながらも動脈血酸素分圧の上昇を来した．同時に呼気終末炭酸ガス濃度も両薬物により一過性に上昇した．以上の結果からflunarizineは脳酸素消費量には何ら影響がなく，さらにpapaverineと比べて持続性の脳血流増加作用を有することが明らかとなった．
- 社団法人 日本薬理学会の論文
著者
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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久保 和博
協和醸酵工業(株)医薬研究所
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JAGENEAU Tony
Janssen Pharmaceutica Applied Pharmacology
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JAGENEAU Tony
Applied Pharmacology, Janssen Pharmaceutica
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