Potentiating Effects of Bradykinin-related Substances on Bradykinin-induced Contraction of Guinea Pig Ileum and Hypotension in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Bradykinin-related substances were studied in vitro and in vivo for bradykinin-potentiating activity. Of the ten peptides which augmented the contractile response of isolated guinea pig ileum to bradykinin, des-Pro^2-bradykinin was the most potent. Its potency was 1.9 times that of potentiator B, a bradykinin potentiating peptide obtained from the venom of Agkistrodon halys blomhoffii. This peptide also potentiated the vasode-pressing activity of bradykinin in rats and inhibited angiotensin converting enzyme. These findings indicate that des-Pro^2-bradykinin, like venom peptides, potentiates the activity of bradykinin, possibly by inhibiting angiotensin converting enzyme (kininase II).
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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成瀬 正織
Medical Service Department Pharmaceuticals Division Kyowa Hakko Kogyo Co. Ltd.
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周藤 勝一
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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木村 皓俊
Peptide Institute, Protein Research Foundation
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榊原 俊平
Peptide Institute, Protein Research Foundation
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山次 貞義
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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山次 貞義
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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周藤 勝一
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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周藤 勝一
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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榊原 俊平
ペプチド研
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木村 皓俊
ペプチド研
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