Studies on Oxytetracycline and Related Compounds. XVIII. Syntheses of 1-Hydroxy-3,10-dimethylanthrone and 6-Hydroxy-12-methyl-5(12H)-naphthacenone.
スポンサーリンク
概要
- 論文の詳細を見る
The Grignard reaction of 1-hydroxy-3-methylanthraquinone (II) with methylmagnesium iodide yielded 1,10-dihydroxy-3,10-dimethylanthrone (III), which was converted to 3,10-dimethyl-1-hydroxyanthrone (VI) by reduction with hydriodic acid. Compound VI was also obtained by hydrolysis with hydrochloric acid of 1,9-diacetoxy-3,10-dimethyl-anthracene (V), which was prepared by reductive acetylation of III with zinc dust, sodium acetate and acetic anhydride. The method was also found to be applicable to 6-hydroxy-5,12-naphthacenequinone (IX), thus giving 6-hydroxy-12-methyl-5 (12H)-naphthacenone (XI).
- 公益社団法人日本薬学会の論文
- 1963-02-25
著者
-
成瀬 正織
Medical Service Department Pharmaceuticals Division Kyowa Hakko Kogyo Co. Ltd.
-
森川 浩一
Faculty of Pharmaceutical Sciences, Osaka University
-
堀井 善一
School of Pharmacy, Osaka University
-
森川 浩一
School of Pharmacy, Osaka University
-
成瀬 正織
School of Pharmacy, Osaka University
-
田村 恭光
School of Pharmacy, Osaka University
-
森川 浩一
Faculty Of Pharmaceutical Sciences Osaka University
関連論文
- Studies on Azasteroids and Related Compounds.I. The Reaction of Ethyl 2-Piperidineacetate with 2-Tetralone
- Synthesis of Des-Pro^2-Bradykinin and Its Behavior in Chromatography
- Potentiating Effects of Bradykinin-related Substances on Bradykinin-induced Contraction of Guinea Pig Ileum and Hypotension in Rats
- Studies on Oxytetracycline and Related Compounds. XVIII. Syntheses of 1-Hydroxy-3,10-dimethylanthrone and 6-Hydroxy-12-methyl-5(12H)-naphthacenone.
- Studies on Oxytetracycline and Related Compounds. XVII. Synthesis of 1,3,11-Trimethoxynaphthacenequinone.
- Synthetic Studies on Sorigenins. VII. Synthesis of α-Sorigenin Dimethyl Ether (3-Hydroxymethyl-1,6,8-trimethoxy-2-naphthoic Acid γ-Lactone). (2).
- Synthetic Studies on Sorigenins. VI. Synthesis of γ-Lactone of 3-Hydroxymethyl-1,6,8-trimethoxy-2-naphthoic Acid (α-Sorigenin Dimethyl Ether). (1).
- Synthetic Studies on Sorigenins. V. Synthesis of γ-Lactone of 3-Hydroxymethyl-4,5,7-trimethoxy-2-naphthoic Acid.
- Synthetic Studies on Sorigenins. IV. Synthesis of γ-Lactone of 3-Hydroxymethyl-4-methoxy-2-naphthoic Acid.
- Synthetic Studies on Sorigenins. III. Syntheses of 4-Methoxynaphtho [2,3-c] furan-1 (3H)-one and 5-Methoxynaphtho [1,2-c] furan-3 (1H)-one.
- Synthetic Studies on Sorigenins. I. Syntheses of γ-Lactones of 1-Methoxy-3-hydroxymethyl-2-naphthoic Acid and 3-Hydroxymethyl-4-methoxy-2-naphthoic Acid.
- Studies on Ergot Alkaloids and Related Compounds. XII. Syntheses of Ethyl 4-Methyl-2,3,4,4α, 5,6-hexahydrobenzo[f]quinoline-2-carboxylate and its Dihydro Derivative
- Studies on Oxytetracycline and Related Compounds. XV. Synthesis and Stereoisomers of 1-Methyl-4-oxo-1,2,3,4-tetrahydro-2-naphthoic Acid.
- Studies on Oxytetracycline and Related Compounds. XIV. Synthesis and Stereoisomers of (α-Methylbenzyl) succinic Acid.
- Studies on Oxytetracycline and Related Compounds. XIII. Synthesis and Stereoisomers of (α-Methylbenzyl) succinic Acid. (2).
- Studies on Oxytetracycline and Related Compounds. XII. Synthesis and Stereoisomers of (α-Methylbenzyl) succinic Acid. (1).
- On the Absolute Configuration of Securinine
- Studies on the Azasteroids and Related Compounds. V. Syntheses of Isomeric Ethyl 3-Methoxy-2-piperidineacetates and 4-Methoxy-1,2,3,4,4a, 5,7,8,9,10-Decahydro-6H-benzo[c]-quinolizin-6-ones
- Studies on the Azasteroids and Related Compounds. IV. Reactions of 1,2,3,4,6a, 7,8,9,10,10a-Decahydro-6H-benzo [c] quinolizin-6-one
- Studies on Azasteroids and Related Compounds. III. On the Cyclodehydration of Cyclic Ketone and β-Aminoester
- Studies on the Azasteroids and Related Compounds. II. Reduction of 1,2,3,4,4a, 5,7,8,9,10-Decahydro-6H-benzo [c] quinolizin-6-one and Related Compounds
- Synthetic Studies on Sorigenins. II. Synthesis of β-Sorigenin Dimethyl Ether.
- Studies on Ergot Alkaloids and Related Compounds. IV. Preparation and Lithium Aluminum Hydride Reduction of Some Vinylogous Lactams.
- 2-Acetyl-1-naphthoic and 2-Acetyl-3,4-dihydro-1-naphthoic Acid.