Studies on Oxytetracycline and Related Compounds. XIV. Synthesis and Stereoisomers of (α-Methylbenzyl) succinic Acid.
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概要
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A method was investigated for the synthesis of (α-methylbenzyl) succinic acid (VII) by dehydration, hydrolysis, and hydrogenation of 3-(α-methylbenzyl) malic acid (XI). Dehydration of 3-(α-methylbenzyl) malic acid (XI) by boiling with acetic anhydride yielded cis- and trans-isomers of (α-methylbenzylidene) succinic anhydride (XII) and (α-methylbenzyl) maleic anhydride (XIII), which were converted to the corresponding dicarboxylic acids by hydrolysis with water.
- 公益社団法人日本薬学会の論文
- 1961-06-25
著者
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堀井 善一
School of Pharmacy, Osaka University
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田村 恭光
School of Pharmacy, Osaka University
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酒井 立夫
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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酒井 立夫
School of Pharmacy, University of Osaka
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