Synthetic Studies on Sorigenins. I. Syntheses of γ-Lactones of 1-Methoxy-3-hydroxymethyl-2-naphthoic Acid and 3-Hydroxymethyl-4-methoxy-2-naphthoic Acid.
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概要
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As an exploratory experiment on syntheses of sorigenins (I), 1-methoxy-3-hydroxymethyl-2-naphthoic acid γ-lactone (VIII) and 3-hydroxymethyl-4-methoxy-2-naphthoic acid γ-lactone (XV) were synthesized. Compound (VIII) was prepared from 3-hydroxymethyl-3,4-dihydro-1 (2H)-naphthalenone (IV) as shown in Chart 1. Compound (XV) was prepared through reduction of 3-ethoxycarbonyl-4-hydroxy-2-naphthoic acid (XVIII) and its methyl ether (XX) with lithium aluminium hydride. Reductions of 1-methoxy-2,3-naphthalenedicarboxylic anhydride (XIV) and of the halfester prepared by alcoholysis of (XIV) with lithium aluminium hydride were found to give a mixture of (VIII) and (XV).
- 公益社団法人日本薬学会の論文
- 1962-10-25
著者
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堀井 善一
School of Pharmacy, Osaka University
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田村 恭光
School of Pharmacy, Osaka University
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加多木 豊之
School Of Pharmacy Osaka University
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田中 悌二
School Of Pharmacy Osaka University
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加多木 豊之
School Of Pharmaceutical Sciences Mukogawa Women 's University
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