Itaconic Acid in Organic Chemistry. I. Synthesis of 2-Methyl-1,4-naphthoquinone (Menadione).
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概要
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Menadione was prepared from itaconic acid according to the reaction scheme described in the text. The direct oxidation of 2-methyl-1-tetralone to menadione (method A) appeared to be more convenient than that described by Sah^<3)> in view of avoiding the processes of the tetralone derivative to 2-methylnaphthalene. Method B was a little tedious but gave a good yield in each process. From these experiments, it could be concluded that itaconic acid is valuable as the staring material for the preparation of menadione.
- 公益社団法人日本薬学会の論文
- 1957-02-20
著者
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堀井 善一
Pharmaceutical Faculty University Of Osaka
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田中 悌二
Pharmaceutical Faculty, University of Osaka
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村上 百合子
Pharmaceutical Faculty, University of Osaka
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田中 悌二
School Of Pharmacy Osaka University
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村上 百合子
Pharmaceutical Faculty University Of Osaka
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- Itaconic Acid in Organic Chemistry. I. Synthesis of 2-Methyl-1,4-naphthoquinone (Menadione).
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