Studies on Terramycin and Related Compounds. IX. Synthesis of 3-(o-Carboxy-phenyl) butyric Acid via the Reformatsky Reaction.

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概要

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• The Reformatsky reaction of ethyl o-acetylbenzoate (II) with ethyl bromoacetate gave ethyl 3-methylphthalide-3-acetate (IIIa) as the product, which was led to 3-(o-car-boxyphenyl) butyric acid (I) via 3-(o-carboxyphenyl) crotonic acid (IVa). The structures of (IIIa) and (IVa) were established by means of their chemical properties and the ultraviolet and infrared absorption spectra, and it was shown that the method was valuable for the verification of each structure of the tautomerism represented by the following general formulae : [chemical formula]

• 公益社団法人日本薬学会の論文
• 1957-02-20

著者

• 堀井 善一

  Pharmaceutical Faculty University Of Osaka

• 二宮 一彌

  Medicinal Chemistry Laboratory Kobe Women's College Of Pharmacy

• 田村 恭光

  Pharmaceutical Faculty, University of Osaka

• 二宮 一彌

  Pharmaceutical Faculty, University of Osaka

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• Studies on Oxytetracycline and Related Compounds. XI. Synthesis of Terranaphthol.
• Studies on Terramycin and Related Compounds. IX. Synthesis of 3-(o-Carboxy-phenyl) butyric Acid via the Reformatsky Reaction.
• Studies on Oxytetracycline and Related Compounds. X. Synthesis of Terranaphthoic Acid.
• Synthesis of 1,8-Dihydroxy-4-methyl-3-naphthoic Acid : Terranaphthoic Acid

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