Synthesis of Des-Pro^2-Bradykinin and Its Behavior in Chromatography
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概要
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Des-Pro^2-Bradykinin was synthesized by the classical solution method as a reference compound for a possible contaminant in synthetic bradykinins, and its behavior in various chromatographic analyses was examined. It showed almost the same Rf values as bradykinin under several different conditions in cellulose thin layer chromatography and in paper electrophoresis, but was clearly separable from bradykinin by reversed phase high performance liquid chromatography under specific conditions. Since des-Pro^2-bradykinin was found to have a potent bradykinin-potentiating activity, contamination by this material should be carefully avoided in bradykinin synthesis.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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成瀬 正織
Medical Service Department Pharmaceuticals Division Kyowa Hakko Kogyo Co. Ltd.
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木村 皓俊
Peptide Institute, Protein Research Foundation
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榊原 俊平
Peptide Institute, Protein Research Foundation
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芳澤 久美子
Peptide Institute, Protein Research Foundation
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榊原 俊平
ペプチド研
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木村 皓俊
ペプチド研
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芳澤 久美子
Peptide Institute Protein Research Foundation
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- 赤堀先生の思い出
- タイトル無し