Synthetic Studies on 1,2-Dehydro-1-carbacephem Compounds

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概要

• 論文の詳細を見る

• 7-Azido-1,2-dehydro-1-carbacephem 13 was efficiently synthesized by employing ketene-imine cycloaddition, intramolecular Horner-Emmons reaction and elimination of a phenylsulfoxide group or an ammonium group. 7-Acylamino 1,2-dehydro-1-carbacephems, 18 and 19,were obtained from 13. Infrared absorption frequencies of the β-lactam carbonyl in 1,2-dehydro-1-carbacephem compounds thus prepared are equal to or higher than those of the corresponding 1-carbacephem compounds. However, 18 and 19 exhibited very poor antibacterial activity.

• 社団法人日本薬学会の論文
• 1989-02-25

著者

• 平田 正

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 斉藤 博満

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• 平田 正

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• 松島 日出夫

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• 白木 千尋

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• 斉藤 博満

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

• 松島 日出夫

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

• 白木 千尋

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

関連論文

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• Synthesis of Quinone Derivatives of Quinocarcin
• Studies on Cadiotonic Agents. IV. : Sunthesis of Novel 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Substituted Hydantoin and 2-Thiohydantoin Rings
• Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
• Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives
• Synthesis and Biological Evaluation of Quinocarcin Derivatives
• Synthesis of 1,2-Disubstituted-1-carbacephem
• Synthesis and Biological Evaluation of 3-Chloro-1-carbacephem Compounds
• Synthesis and Biological Evaluation of Optically Active 3-H-1-Carbacephem Compounds
• Synthetic Studies on 1,2-Dehydro-1-carbacephem Compounds
• New Synthetic Approach to 3H-Carbacephems : Synthetic Studies on 1-Carbacephem Antibiotics
• Synthesis of 2-Amino-2-deoxy-β-D-arabinofuranosyl Nucleosides
• Synthesis of Purine Nucleoside Nitrosoureas and Their Antitumor Activities
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