Effect of Pregnancy on the Disposition of Valproate in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The disposition of sodium valproate in pregnant rats was studied comparing with nonpregnant (control) rats. In the pregnant rats, the total plasma clearance decreased significantly (p<0.05) from 7.06 ml/min/kg of the control to 5.34 ml/min/kg, whereas the plasma elimination half-life of valproate did not change. The serum unbound fraction (f_s) of pregnant rats increased remarkably. The f_s of the fetal plasma was lower than that of the maternal serum in spite of the lower albumin (main binding protein for valproate) concentration in the fetal plasma. A non-linear serum (plasma) protein binding was observed both in the control and the fetal rats, but not observed in the pregnant rats. In the pregnant rats, the tissue-to-plasma concentration ratio (K_p) of the brain was higher than that in the control rats, whereas the K_p values of the liver and lung were lower than those in the control rats. In other tissues, the K_p values did not show a significant difference. Rapid placental transfer was observed and the K_p value of the fetus was 0.43.
- 公益社団法人日本薬学会の論文
著者
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KOBAYASHI Satoshi
Pharmaceuticals Research and Development Division, Kyowa Hakko Kogyo Co., Ltd.
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Hanano Manabu
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:department Of Pharmacy University Of
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Iga Tatsuji
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:department Of Pharmacy University Of
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TAKAI Katsumi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Takai Katsumi
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.:department Of Pharmacy University Of
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Katagiri S
Faculty Of Engineering Niigata University
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Kobayashi Satoshi
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kobayashi Satoshi
Analytical & Pharmacokinetic Laboratories Pharmaceutical Research Institute Kyowa Hakko Hagyo Co
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