Pharmacological Studies on the Mechanism of Gastric Ammonia Production in Relation to Peptic Ulcer Remedies.
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概要
- 論文の詳細を見る
1. Relationship between urease activity in gastric mucosa and ammonia content of gastric juice was examined in 3 species of laboratory animals. The close relation was confirmed between them. 2. Urease inhibitory effects of some agents were compared in vivo and their influence on gastric ammonia production was examined in mice. Benzohydroxamic acid, a specific inhibitor of urease, distinctively reduced gastric ammonia production. 3. By intravenous injection of urea, ammonia content of gastric juice was markedly increased. 4. Repeated administrations of urea activated gastric urease activity and gastric ammonia production. 5. Repeated administrations of urea reduced the incidence of gastric errosion which was induced by reserpine in mice. 6. All these results may suggest the important role of gastric urease in defensive mechanism of gastric mucosa.
- 公益社団法人日本薬学会の論文
- 1967-11-25
著者
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渡辺 和夫
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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福田 英臣
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)faculty Of Pharmaceutical
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大島 幸子
Faculty of Pharmaceutical Sciences, Nagoya City University
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大島 幸子
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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