Influence of Some Drugs Injurious to Gastric Mucosa on Gastric Ammonia Formation
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概要
- 論文の詳細を見る
Mechanism of gastric ammonia formation was studied in mice, and the possibility was examined that the injurious effect of some anti-inflammatory drugs on gastric mucosa was due to the gastric urease inhibition. Ammonia formation in the stomach was remarkably augmented by urea irrigation and was inhibited by benzohydroxamic acid, an urease inhibitor. These results indicate the importance of urease in ammonia formation in stomach. Urease inhibiting-activity in vitro of three anti-inflammatory drugs, aspirin, phenylbutazone and chinophen, and of caffeine were so weak that their injurious effects to gastric mucosa could not be attributed to urease inhibition. Gastric ammonia formation in vivo was found to be accelerated by irrigation of gastric mucosa with above-mentioned drugs, except aspirin. Gastric ammonia formation was also increased by eugenol, a well-known gastric mucosa irritant, and the effect was completely inhibited by benzohydroxamic acid. From these results it is concluded that injury on gastric mucosa by drugs increases gastric ammonia formation by accelerating the enzymatic reaction between urea and urease.
- 公益社団法人日本薬学会の論文
- 1970-02-25
著者
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渡辺 和夫
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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福田 英臣
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)faculty Of Pharmaceutical
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石田 典子
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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