Bufadienolides. III. Reduction of Resibufogenin with Sodium Borohydride
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概要
- 論文の詳細を見る
Partial reduction of resibufogenin (III) having 14β, 15β-epoxide with sodium borohydride under various conditions was examined. No bufalin (IV) corresponding 14β-hydroxy compound was obtained in any case, but instead there was produced 14β, 15β-epoxy-5β-chol-20 (22)-ene-3β, 21,24-triol (V) by the cleavage of an α-pyrone ring. Then V was converted into the corresponding triacetate (VI), bromide (VII) and saturated compound (VIII). The result of this reaction differed that of the reaction of Marinobufagin (I), which was reported to yield Telocinobufagin (II) corresponding 14β-hydroxy compound. In our case, it is interesting that 14β, 15β-epoxy ring is intact by the treatment with sodium borohydride whereas the α-pyrone ring cleavages smoothly to afford Δ^<20 (22)>-compound. This reaction mechanism was considered to be as depicted in Chart 3.
- 公益社団法人日本薬学会の論文
- 1969-06-25
著者
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山本 博
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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釜野 徳明
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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小松 曼耆
Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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小松 曼耆
Research Laboratory Taisho Pharmaceutical Co. Ltd.:(present Address)faculty Of Pharmaceutical Scienc
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釜野 徳明
Research Laboratories Taisho Pharmaceutical Co. Ltd.
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釜野 徳明
アリゾナ州立大学ガン研
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釜野 徳明
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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