紫根の成分研究(第2報) : 軟紫根と硬紫根の脂溶性画分の含量,成分,および抗菌性

概要

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The ether extracts [A] of "Nanshikon" (Macrotomia euchroma PAULS) and "Koshikon" (Lithospermum erythrorhizon SIEB. et Zucc.) were submitted on columnchromatography to yield petroleum ether soluble fraction [B]. Frac. [B] was extracted with acetone [C], which was columnchromatographed to elute shikonin derivatives. Each content of [A], [B], [C] in "Nanshikon" was twice than those of "Koshikon". The total contents of shikonin derivatives in "Nanshikon" were three times higher than those of "Koshikon". Frac. [B] was treated with NaOH and extracted with petroleum ether, in which paraffins and alcohols were found. Each [A], [B], [C] and shikonin derivatives except for anhydroalkannin inhibited the growth of Staphylococcus aureus, Staphylococcus epidermidis, Sarcina lutea, Bacillus subtilis, but not that of Escherichia coli, Pseudonionas aeroginosa. Each [A], [B], [C] and some shikonin derivatives inhibited a little the growth of Saccharomyces cerevisiae.
日本生薬学会の論文
1973-06-20