Metabolic Fate of 1-Ethynylcyclohexyl Carbamate. V. Studies on 1-Ethynyl-1,2-cyclohexanediol in the Urine of Man receiving 1-Ethynylcyclohexyl Carbamate.
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A metabolite of 1-ethynylcyclohexyl carbamate other than 1-ethynyl-4-hydroxycyclohexyl carbamate and its glucuronide was isolated from urine of man receiving the drug. The metabolite was identified as 1-ethynyl-trans-1,2-cyclohexanediol by comparing the metabolite and its reduced product with synthetic samples. Paper chromatography with three kinds of solvent system and paper electrophoresis were employed for the identification.
- 公益社団法人日本薬学会の論文
- 1961-04-25
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