Efficacy and Limitations of Stereotactic Radiosurgery in the Treatment of Glioblastoma
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of recurrent glioblastoma is still challenging. Stereotactic radiosurgery has been accepted as a treatment option for recurrent glioblastoma after standard chemotherapy and irradiation. However, the efficacy of stereotactic radiosurgery at recurrence has been limited, mainly due to the highly infiltrative nature of the tumor which makes the lesion difficult to define as the target. To enhance the efficacy of stereotactic radiosurgery, several methods of targeting based on neuroimaging technology such as positron emission tomography and magnetic resonance imaging have been adopted to irradiate as many of the viable tumor cells as possible and showed some enhanced efficacy. In a trial of intensified treatment by extending the irradiation field, improvement of local control did not result in longer survival. Radiation-induced adverse event is another problem after stereotactic radiosurgery for recurrent glioblastoma because almost all patients underwent irradiation as a part of the initial treatment. To overcome the side effects associated with re-irradiation, use of bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor, has shown some efficacy. Advances in irradiation technology, neuroimaging, and adjuvant treatment are needed to enhance the efficacy of stereotactic radiosurgery for recurrent glioblastoma and reduce the morbidity associated with irradiation.
- 2012-08-15
著者
-
Saito Nobuhito
Department Of Neurosurgery Faculty Of Medicine Tokyo University
-
Koga Tomoyuki
Department Of Molecular Chemistry And Biochemistry Faculty Of Science And Engineering Doshisha University
関連論文
- Transient Asystole During Surgery for Posterior Fossa Meningioma Caused by Activation of the Trigeminocardiac Reflex : Three Case Reports
- Symptomatic T2 Vertebral Hemangioma in a Pregnant Woman Treated by One Stage Combination Surgery ; Posterior Stabilization and Anterior Subtotal Tumor Resection : Case Report
- Basilar Bifurcation Aneurysms : Endovascular Treatment Versus Craniotomy
- Aggregation Induced α-Helix/β-Sheet Transition of the Poly(ethylene glycol)-attached Peptide
- Intraoperative Fluorescence Detection of Malignant Gliomas Using 5-Aminolevulinic Acid
- Endovascular Treatment of Asymptomatic Cerebral Aneurysms : Anatomic and Technical Factors Related to Ischemic Events and Coil Stabilization
- Management of Asymptomatic Cerebral Aneurysms Based on the Treatment Results of Recent 5 Years
- Stereotactic Radiosurgery for Skull Base Meningioma
- Retrospective Survey of Endovascular Treatment for Ruptured Intracranial Aneurysm in Japan : Retrospective Endovascular Subarachnoid Aneurysm Treatment (RESAT) Study
- The detection and quantification of highly reactive oxygen species using the novel HPF fluorescence probe in a rat model of focal cerebral ischemia
- Does Hypoxic Preconditioning Induce Angiogenesis and Protect against Focal Cerebral Ischemic Damage in Rats ?
- Immunohistochemical analysis of cleaved caspase-3 detects high level of apoptosis frequently in diffuse large B-cell lymphomas of the central nervous system
- Nestin Expression in Vascular Malformations : A Novel Marker for Proliferative Endothelium
- Anterior Transpetrosal Approach for Pontine Cavernous Angioma
- Structurally and Temporally Regulated Peptide Self-Assembly into Nanofibers
- Atypical Osteomyelitis of the Skull Base and Craniovertebral Junction Caused by Actinomyces Infection : Case Report
- Regulation of Self-assembling Process of a Cationic β-Sheet Peptide by Photoisomerization of an Anionic Azobenzene Derivative
- Controlling the Aggregation Behavior of Amyloid β Peptide by Poly(ethylene glycol)-Conjugated Oligopeptides
- Treatment of a Cervical Carotid Pseudoaneurysm That Occurred Years After Laryngectomy and Irradiation of a Neck Tumor : Case Report
- Familial Lateral Temporal Lobe Epilepsy Confirmed With Intracranial Electroencephalography and Successfully Treated by Surgery : Five Case Reports in One Family
- Inositol 1,4,5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B
- Evidence-Based Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage English Edition
- Morphological Variation of Peptide-synthetic Hybrid Block Copolymer Assemblies in Nonaqueous Media
- β-Sheet peptide-assisted polymerization of diacetylene at the air-water interface and thermochromic property
- Mesenchymal Chondrosarcoma of the Orbit
- Efficacy and Limitations of Stereotactic Radiosurgery in the Treatment of Glioblastoma
- Role of Gamma Knife Radiosurgery in Neurosurgery : Past and Future Perspectives
- Neuroendoscopic Transnasal Surgery for Skull Base Tumors : Basic Approaches, Avoidance of Pitfalls, and Recent Innovations
- Mesenchymal Chondrosarcoma of the Orbit : Case Report
- Comparative Analysis of Spinal Hemangioblastomas in Sporadic Disease and Von Hippel-Lindau Syndrome
- A Pitfall of the Volume Rendering Method with 3D Time-of-Flight MRA: A Case of a Branching Vessel at the Aneurysm Neck
- Role of Stereotactic Radiosurgery in the Treatment of High-Grade Cerebral Arteriovenous Malformation
- Novel Method for Analyzing Locomotor Ability After Spinal Cord Injury in Rats: Technical Note
- Toxicity and Outcome of Radiotherapy with Concomitant and Adjuvant Temozolomide in Elderly Patients with Glioblastoma: A Retrospective Study
- Ptosis as Partial Oculomotor Nerve Palsy Due to Compression by Infundibular Dilatation of Posterior Communicating Artery, Visualized with Three-Dimensional Computer Graphics: Case Report
- Obituary: Keiji SANO, MD, PhD, 1920–2011
- Site-specific adsorption of gold nanoparticles coated with thermo-responsive peptides
- Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency
- A Pitfall of the Volume Rendering Method with 3D Time-of-Flight MRA : A Case of a Branching Vessel at the Aneurysm Neck