Novel Method for Analyzing Locomotor Ability After Spinal Cord Injury in Rats: Technical Note
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概要
- 論文の詳細を見る
In the research for the treatment of spinal cord injury (SCI), the evaluation of motor function in model rats must be as objective, noninvasive, and ethical as possible. The maximum speed and acceleration of a mouse measured using a SCANET system were previously reported to vary significantly according to severity of SCI. In the present study, the motor performance of SCI model rats was examined with SCANET and assessed for Basso–Beattie–Bresnahan (BBB) score to determine the usefulness of the SCANET system in evaluating functional recovery after SCI. Maximum speed and acceleration within the measurement period correlated significantly with BBB scores. Furthermore, among several phased kinematic factors used in BBB scores, the capability of "plantar stepping" was associated with a drastic increase in maximum speed and acceleration after SCI. Therefore, evaluation of maximum speed and acceleration using a SCANET system is a useful method for rat models of SCI and can complement open field scoring scales.
著者
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Saito Nobuhito
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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YASUDA AKIMASA
Department of Rehabilitation, Hachiohji Health Cooperative Shiroyama Hospital
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Shinozaki Munehisa
Department Of Neurosurgery Faculty Of Medicine Tokyo University
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Nakamura Masaya
Department Of Applied Microbiology Forestry And Forest Products Research Institute
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Toyama Yoshiaki
Department Of Orthopaedic Surgery Keio University
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Okano Hideyuki
Department Of Molecular Neurobiology Institute Of Basic Medical Sciences And Center For Tara(tsukuba
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SAITO Nobuhito
Department of Neurosurgery, Graduate School of Medicine, University of Tokyo
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NAKAMURA Masaya
Department of Orthopedic Surgery, Keio University School of Medicine
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NORI Satoshi
Department of Orthopedic Surgery, Keio University School of Medicine
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YASUDA Akimasa
Department of Orthopedic Surgery, Keio University School of Medicine
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