Localization and developmental changes of mRNA for CDP-diacylglycerol synthase in rat central nervous system.
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概要
- 論文の詳細を見る
CDP-diacylglycerol synthase (CDS) catalyzes the reaction of CTP and phosphatidic acid to form CDP-diacylglycerol and inorganic pyrophosphate. In this study, we isolated and sequenced a rat CDS clone that encodes an amino acid sequence highly homologous to the human CDS sequence. With the use of the cloned cDNA, we investigated the distribution of the mRNA in the adult rat central nervous system by in situ hybridization. The CDS transcript was widely distributed throughout the brain, although signal intensities were somewhat variable. The mRNA was moderately expressed in the mitral cell layer of the olfactory bulb, pirform cortex, neocortex layer V/VI, dentate gyrus, CAl-4 regions of hippocampus, Purkinje cell layer of the cerebellum, and dorsal root ganglion. In neocortex layers II/III and IV, amygdala, hypothalamus, and granule cells of the cerebellum were relatively few, but significant levels of the CDS transcript were observed. We also studied the developmental changes in the expression of the CDS mRNA in the olfactory bulb, hippocampus, cerebellum and spinal cord by the method of reverse transcription-polymerase chain reaction. Dramatic increases in the expression of the CDS mRNA were seen during the early stage of postnatal growth.
- 北関東医学会の論文
著者
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Fukusato Toshio
Department Of Pathology Gunma University Hospital
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Miyamoto Kaoru
Biosignal Research Center Institute For Molecular And Cellular Regulation Gunma University
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Imai Hideaki
Department Of Electronic And Information Engineering Faculty Of Engineering Hokkaido University
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Hosaka Kohei
Department of Basic Allied Medicine, Gunma University
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Mizutani Tetsuya
Biosignal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
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Imai Hideaki
Department of Neurosurgery, Gunma University School of Medicine
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Imai Hideaki
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
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Hosaka Kohei
Department of Basic Allied Medicine, Gunma University School of Health Sciences
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