Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis
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概要
- 論文の詳細を見る
Epigallocatechin 3-gallate (EGCG) has cytotoxic effects in many cancer cells. It has been reported that A549 lung cancer cells are markedly resistant to cell death induced by EGCG. In the present study, the effects of EGCG on A549 lung cancer cell growth and angiogenesis were studied. We found that EGCG dose-dependently suppressed A549 cell growth, while A549 cells were markedly resistant to cell death in vitro. Next we next found that EGCG increased endostatin expression and suppressed vascular endothelial growth factor (VEGF) expression. We further studied to determine whether EGCG would suppress A549 tumor growth in nude mouse and angiogenesis. EGCG in drinking water significantly suppressed A549 tumor growth in nude mice. Histological analysis revealed that the number of CD34 positive vessels had a tendency to decrease in the tumor. In sum, EGCG had anti-proliferative effects of A549 on tumor growth and showed a tendency to suppress angiogenesis.
著者
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Fukusato Toshio
Department Of Pathology Gunma University Hospital
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Kubota Shunichiro
Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo
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SAKAMOTO Yuhi
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
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TERASHITA Nobuhiro
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
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MURAGUCHI Takashi
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
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