Effects of Differentiation-Inducing Factor-1 (DIF-1) of Dictyostelium discoideum on Bacteria, Fungi, and an Influenza Virus.
スポンサーリンク
概要
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Background & Aims : Differentiation-inducing factor-1 (DIF-1) is a small lipophilic substance that induces stalk cell differentiation in the cellular mold <I>Dictyostelium discoideum</I>. It has been shown that DIF-1 has an anti-tumor activity in mammalian cells. In the present study, we examined the effects of DIF-1 on the growth of some bacteria, fungi, and an influenza virus.<BR>Method : We used <I>in vitro</I> systems for the assay for growth of microorganisms.<BR>Results : DIF-1 did not show marked effect on the bacteria and fungi tested. Interestingly, DIF-1 inhibited viral plaque formation in its host Madin-Darby canine kidney (MDCK) cells in a dose dependent manner and IC<SUB>50 </SUB>was 18μM. DIF-1 also inhibited the growth of MDCK cells and IC<SUB>50</SUB> was 30μM.<BR>Conclusions : These results indicate that DIF-1 or its analogs may be utilized as a tool for the analysis of virus functions.
- 北関東医学会の論文
著者
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Kubohara Yuzuru
Biosignal Research Center Institute For Molecular And Cellular Regulation Gunma University
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Hosaka Kohei
Department of Basic Allied Medicine, Gunma University
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Kuno Masako
Toyama Chemical Co. Ltd.
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Shimakura Masako
Toyama Chemical Co. Ltd.
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Furuta Yousuke
Toyama Chemical Co. Ltd.
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Terashima Nobuo
Toyama Chemical Co. Ltd.
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Kubohara Yuzuru
Biosignal Research Center, Institute for Molecular and Cellular Regulation (IMCR), Gunma University
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