ARSENIC ACCUMULATION DECREASED IN METALLOTHIONEIN NULL CISPLATIN-RESISTANT CELL LINES
スポンサーリンク
概要
- 論文の詳細を見る
Metallothionein (MT) is known to play an important role in the resistance of tumor cells to cis-diamminedichloroplatinum (II) (cisplatin). To identify non-MT factors of cisplatin resistance, we characterized cisplatin-resistant cell lines derived from MT- null cells. All of the cisplatin-resistant MT- null cell lines, namely MKCr-1, -3, -4, -12, and -13, showed strong cisplatin resistance and decreased platinum accumulation. Some multidrug resistance proteins (MRPs) have been reported to contribute to cisplatin resistance. However, no significant difference of the MRPs was observed in any of these cell lines. The MKCrs showed cross-resistance to other metals such as arsenite, arsenate, cadmium and antimony. The arsenate and arsenite sensitivities were highly correlated with sensitivity to cisplatin. In addition, the degree of arsenite accumulation was correlated with the degree of cisplatin accumulation. These results suggest that the cisplatin resistance was strongly correlated with the arsenite transport mechanism in these cells.
- 2007-08-17
著者
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SUZUKI Toshihiro
Department of Materials Technology, Faculty of Engineering, Chiba University
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TOGAWA Tadayasu
Departments of Analytical Biochemistry, Meiji Pharmaceutical University
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TANABE Shinzo
Departments of Analytical Biochemistry, Meiji Pharmaceutical University
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Tanabe S
Departments Of Analytical Biochemistry Meiji Pharmaceutical University
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Tanabe S
Meiji Coll. Pharmacy Tanashi Jpn
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Tanabe Shinzo
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Suzuki T
Departments Of Analytical Biochemistry Meiji Pharmaceutical University
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Togawa T
Departments Of Analytical Biochemistry Meiji Pharmaceutical University
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Togawa Tadayasu
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Suzuki T
Department Of Xenobiotic Metabolism And Molecular Toxicology Institute Of Pharmaceutical Sciences Hi
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OHATA Shigeki
Department of Analytical Biochemistry, Meiji Pharmaceutical University
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HIMENO Seiichiro
Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Himeno Seiichiro
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Ohata Shigeki
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Tsujino Seiichi
Department Of Peripheral Nervous System Research National Institute Of Neuroscience Ncnp
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Himeno Seiichiro
Laboratory Of Molecular Nutrition And Toxicology Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Suzuki Toshihiro
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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