Semiquantitative Vestibulotoxicity to Subablative and Ablative Treated Gerbil Cristae Using Gentamicin or Streptomycin
スポンサーリンク
概要
- 論文の詳細を見る
Semiquantitative histological evaluation was performed on inner ears from Mongolian gerbils to study vestibular damages using ototoxic drugs. Comparisons were made between animals receiving five daily injections of gentamicin/gelfoam slurry, streptomycin/gelfoam slurry, saline/gelfoam slurry and noninjected controls. For gentamicin treated ears, when percent decrease of nuclei in sensory cell layer was compared, the damage to the sensory cells was significantly more severe in the posterior crista than in the superior and lateral crista from two of three gerbils. For streptomycin treated ears, when percent decrease of nuclei in sensory cell layer was compared, the damage to the posterior crista was similar to superior and lateral crista. These results indicate that our models are useful for detecting different vestibulotoxicity among three cristae.
- 日本組織細胞化学会の論文
著者
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YAMAMOTO Satoshi
Department of Physiology, Kurume University School of Medicine
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SUZUKI Toshihiro
Department of Materials Technology, Faculty of Engineering, Chiba University
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SLEPECKY Norma
Institute for Sensory Research
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Hisa Yasuo
Department of Otolaryngology, Kyoto Prefectural University of Medicine
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Yamamoto Satoshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Suzuki Toshihiro
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Suzuki T
Department Of Otolaryngology-head And Neck Surgery Kyoto Prefectural University Of Medicine
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Hisa Yasuo
Department Of Anatomy And Cell Science Kansai Medical University
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Yamamoto S
Department Of Otolaryngology-head And Neck Surgery Kyoto Prefectural University Of Medicine:institut
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Yamamoto Satoshi
Department Of Biochemistry Nagoya University School Of Medicine
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