78(P2-8) アカメガシワ果皮の細胞毒性成分の研究(ポスター発表の部)

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概要

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• Mallotus japonicus MUELL. ARG. (Euphorbiaceae) is a deciduous tree that sprouts red-colored buds and is widely distributed in Japan. The leaves of the tree are used as a treatment for boils. We have examined cytotoxic constituents in pericarps of the tree. In a investigation of the CHCl_3-soluble fraction, which was found to show significant cytotoxic activity in the KB cell culture system, eight new phloroglucinol derivatives named mallotolerin (5), isomallotolerin (6), mallotochromene (7), butyrylmallotochromene (8), isobutyrylmallotochromene (9), mallotophenone (10), mallotochromanol (11) and isomallotochromanol (12) were isolated together with five known compounds, 1-4 and 13. Their structures have been characterized by their respective chemical and spectral data. The unambiguous assignments of ^<13>C-NMR spectra of compounds 7-10 and 12 were performed by means of 2D NMR of long rang ^1H-^<13>C shift correlation. These compounds were assessed for growth inhibiting activity against KB, human larinx (Hep-2) and lung (PC-13) carcinoma cells as well as mouse B-16 melanoma, leukemias P-388 and L-5178Y cells. Most of these derivatives were prove to be significantly cytotoxic in culture. One of them 3-(3,3-dimethylally1)-5-(3-acety1-2,4-dihydroxy-5-methy1-6-methoxybenzy1)-phroracetophenone (1) showed an excellent cytotoxicity against all target tumor cells and marked prolongation of life-span in mice bearing L-5178Y. Analysis of the DNA histogram obtained by flow cytometry showed that 1 inhibited the cell cycle progression.

• 天然有機化合物討論会の論文
• 1989-09-17

著者

• 越村 三郎

  Department of Serology, Kanazawa Medical University

• 手塚 康弘

  富山医薬大和漢薬研究所化学応用部門

• 林 利光

  富山医科薬科大学薬学部

• 有澤 宗久

  富山医薬大・薬

• 藤田 章夫

  富山医薬大・薬

• 林 利光

  富山医薬大・薬

• 森田 直賢

  富山医薬大・薬

• 菊池 徹

  富山医薬大・和漢研

• 越村 三郎

  金沢医大・血清

• 有澤 宗久

  富山医科薬科大学薬学部

• 菊池 徹

  富山医科薬科大学和漢薬研究所化学応用部門

• 森田 直賢

  Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceut

• 藤田 章夫

  Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences:toyoma Medical And Pharmaceutic

• 林 利光

  富山医科薬科大学薬学部生薬学教室

• 菊池 徹

  富山医薬大和漢薬研化学応用

• 手塚 康弘

  富山医薬大 和漢薬研

• 林 利光

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 越村 三郎

  Department Of Serology Kanazawa Medical University

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