Terpenoids. LIII. : Antitumor Activity of Trichorabdals and Related Compounds

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概要

• 論文の詳細を見る

• Among the three types, enmein-, oridonin-, and trichorabdal-type, of diterpenoids from Rabdosia trichocarpa, the latter showed the highest antitumor activity against Ehrlich ascites carcinoma in mice. Their potent activities were attributed to synergistic increase arising from the presence of two active sites in one molecule. In vitro activity against HeLa cells and in vivo activity against P 388 lymphocytic leukemia of diterpenoids and related compounds were also determined, but no synergistic increase in activity due to plural active sites was observed in those cases.

• 公益社団法人日本薬学会の論文
• 1989-06-25

著者

• 武田 節夫

  Tokushima Institute, Taiho Pharmaceutical Co., Ltd.,

• 武田 節夫

  Research Institute, Taiho Pharmaceutical Co., Ltd.,

• 野出 学

  Kyoto Pharmaceutical University

• 野出 学

  Institute For Chemical Research Kyoto University

• 藤田 榮一

  Osaka University of Pharmaceutical Sciences

• 冨士 薫

  Institute For Chemical Research Kyoto University

• 藤田 栄一

  京都大学化学研究所

• 藤田 栄一

  Osaka University Of Pharmaceutical Sciences

• 佐井 みどり

  Faculty of Pharmaceutical Sciences, Setsunan University

• 采見 憲男

  Research Laboratory, Taiho Pharmaceutical Co., Ltd.,

• 采見 憲男

  Tokushima Institute Taiho Pharmaceutical Co. Ltd.

• 釆見 憲男

  Research Laboratory Taiho Pharmaceutical Co. Ltd.

• 武田 節夫

  Tokushima Institute Taiho Pharmaceutical Co. Ltd.

• 佐井 みどり

  Faculty Of Pharmaceutical Sciences Setsunan University

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