Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

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概要

• 論文の詳細を見る

• The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.

著者

• Azuma Yasu-Taka

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University G

• Matsuo Yukiko

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University G

• Nakajima Hidemitsu

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University G

• Yancopoulos George

  Regeneron Pharmaceuticals, Inc., USA

• Valenzuela David

  Regeneron Pharmaceuticals, Inc., USA

• Murphy Andrew

  Regeneron Pharmaceuticals, Inc., USA

• Karow Margaret

  Regeneron Pharmaceuticals, Inc., USA

• Takeuchi Tadayoshi

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University G

• Yancopoulos George

  Regeneron Pharmaceuticals Inc

• Matsuo Yukiko

  Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien

• Murphy Andrew

  Regeneron Pharmaceuticals Inc.

• Valenzuela David

  Regeneron Pharmaceuticals Inc.

• Azuma Yasu-taka

  Laboratory Of Veterinary Pharmacology Division Of Veterinary Science Osaka Prefecture University Gra

• Takeuchi Tadayoshi

  Laboratory Of Veterinary Pharmacology Division Of Veterinary Science Osaka Prefecture University Gra

• Nakajima Hidemitsu

  Laboratory Of Veterinary Pharmacology Division Of Veterinary Science Osaka Prefecture University Gra

関連論文

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