酵素阻害活性による漢方処方の検討(第5報)Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesteraseによる半夏瀉心湯, 甘草瀉心湯, 生姜瀉心湯の研究
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Fifty-nine species of extracts of Chinese herbal medicinal prescription were tested for inhibitory activity of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase (PDE). Kanzo-shashin-to showed the highest activity in these prescriptions. Kanzo-shashin-to, Hange-shashin-to and Shokyo-shashin-to, whose constracting crude drugs were very similar, were especially studied among these prescriptions. Pinellia tuber acted as an ascent component for Scutellaria root and a mitigatory component for Giycyrrhiza. Jujube acted as a mitigatory component for Glycyrrhiza. Ginger acted as an additional component for Scutellaria root in cAMP PDE test. This additional effect of 6-gingerol, 6-shogaol from Ginger and baicalin from Scutellaria root were investigated.
- 社団法人日本薬学会の論文
- 1991-11-25
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