Pharmacological Studies of Ignavine, an Aconitum Alkaloid

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概要

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• Pharmacological properties, especially, analgesic, antipyretio, antiinflammatory, sedative and antidiuretic activities, of ignavine, one of the main alkaloids in Aconite root, are discussed on the basis of the results of blind screening. Ignavine showed antiinflammatory activity in the acetic acid-induced writhing and carrageenin paw edema tests at doses of 50 and 100 mg/kg p.o., which did not produce undesirable effects such as sedation, motor incoordination, muscle relaxation, hypothermia, ulceration or antidiuresis. Pharmacological properties of mesaconitine are also discussed; mesaconitine showed antiinflammatory, antipyretic and weak sedative activities.

• 公益社団法人日本薬学会の論文
• 1982-05-25

著者

• 上山 敬司

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  Sato Pharmaceutical Co. Ltd.

• 岡本 敏彦

  Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of

• 斎藤 洋

  東京医科歯科大学医用器材研究所

• 中 信子

  Experimental Station For Medicinal Plant Studies Faculty Of Pharmaceutical Sciences University Of To

• 斎藤 洋

  Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of

• 上山 敬司

  Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of

• 八木 純

  Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of

• 八木 純

  Experimental Station For Medicinal Plant Studies Faculty Of Pharmaceutical Sciences University Of To

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