Reaction Mechanism in Aromatic Heterocyclic Compounds. V. Kinetics of the Reaction of 4-Nitroquinoline 1-Oxide and Related Compounds with Thioglycolic Acid.

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概要

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• 4-Nitroquinoline 1-oxide and related compounds react easily with SH-group of thioglycolic acid affording the corresponding sulfides of these compounds. With these nitro compounds, the present authors studied the nucleophilic substitution reaction between 4-nitro group and thioglycolic SH-group, and determined the reaction rate constants, energies of activation and entropies of activation in several kinds of solvent system. On the other hand, 4-nitroquinoline 1-oxide and some related compounds have been known to be skin cancer producing agents. Then, the chemical activity of 4-nitro groups which were obtained were discussed on comparison with the carcinogenic activity.

• 公益社団法人日本薬学会の論文
• 1963-06-25

著者

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  Sato Pharmaceutical Co. Ltd.

• 伊藤 道也

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 伊藤 道也

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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