P-8 海洋由来Penicillium属真菌の培養液から得られた新規アルカロイドの構造(ポスター発表の部)

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During a search for new natural products exhibiting biological activities, we screened extracts derived from marine organisms and found that a fungus, Penicillium sp., isolated from the mussel, Mytilus edulis, showed cytotoxic activity against HeLa cells. Bioassay-guided isolation afforded four new alkaloids, notoamides A-D (1-4), along with known compounds, stephacidin A (5) and desoxybreviamide E (6). The compounds 1-6 were identified to be alkaloids derived from tryptophane and proline. New compounds 1-3 contain dihydroxypyrano-2-oxyindole ring, and additionally 1 and 2 have an unusual bicyclo[2.2.2]diazaoctane ring, which has been proposed to be synthesized by an intramolecular Diels-Alder reaction. Compound 1 has a 1-hydroxy-2-oxindole ring: this is the first report of isolation of a 1-hydroxy-2-oxindole metabolite from natural resources. Compounds 1-3 showed moderate cytotoxic activity against HeLa and L1210 cells.
天然有機化合物討論会の論文
2006-09-15