48 ホヤ幼生の付着・変態を促進する海洋生物由来の化合物(口頭発表の部)

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Larvae of marine benthic organisms are believed to initiate settlement, followed by metamorphosis, upon reception of chemical cues. Although the phemomena are known for a wide range of marine organism, those which cues were identified are quite few. In the course of our studies on mechanisms of marine biofouling, we have found that extracts from ascidians (Ciona savignyi, Halocynthia roretzi, Styela plicata, and Botrylloides sp.) and the brown alga (Sargassum thunbergii) promoted larval settlement and metamorphosis in ascidians. We describe the isolation and identification of active substances from these organisms. The tunic of C. savignyi was extracted with MeOH, whose extract was fractionated to obtain two active compounds, urochordamines A and B. Their structures were elucidated by spectroscopic methods to be new pteridine-containing bromophysostigmine alkaloids. They were also isolated from the tunicate Botrylloides sp. Urochordamine A promoted larval settlement and metamorphosis in C. savignyi at a concentration of 2ng/mL. Upon standing in MeOH urochordamines A and B were converted to more polar urochordamines A' and B'. The order of promoting activity was A'>A>B>B' when tested with H. roretzi larvae. In addition, hypoxanthine, uridine, inosine, guanosine, 2'-deoxyinosine, and 2'-deoxyguanosine were obtained as active principles from both H. roretzi and S. plicata, while phlorotannins and sulfoquinovosyl diacylglycerol were identified as active components from S. thunbergii. The structural features of the promoters suggest that purine and pyrimidine bases may play an important role in the larval settlemnt and metamorphosis process.
天然有機化合物討論会の論文
1993-09-10

48 ホヤ幼生の付着・変態を促進する海洋生物由来の化合物(口頭発表の部)

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