P-41 群体ボヤLissoclinum cf. badiumから単離した新規Lissoclibadin類(ポスター発表の部)

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Ascidians (tunicates, Ascidiacea) are important bioresources for bioactive secondary metabolites. The characteristic feature of compounds obtained from ascidians is nitrogenous structures. Many interesting alkaloids have been isolated from ascidians and showed various biological activities. We have reported seven new polysulfur aromatic alkaloids, lissoclibadins 1-7, together with four known compounds from an Indonesian ascidian Lissoclinum cf. badium (Polyclinidae) collected in the coral reef at North Sulawesi. These compounds were dopamine derivatives possessing heterocyclic rings with sulfur atoms. Because of the unique structures and efficient bioactivities, we continued the isolation of new lissoclibadin derivatives from this ascidian, and seven new compounds, named lissoclibadins 8 (1), 9 (2), 10 (3), 11 (4), 12 (5), 13 (6), and 14 (7), were isolated. The structures of new compounds were assigned on the basis of their spectroscopic data. These compounds were unique polysulfur dopamine derivatives with tetramic (1), trimeric (2), dimeric (3, 4, and 5), and monomeric (6 and 7) structures. Compounds 1, 2, 6, and 7 showed the growth inhibitory activity against the murine leukemia cell line L1210 at IC_<50> values of 2.00 (2.54), 0.38 (0.30), 2.20 (0.70), and 1.80 (0.64)μM (μg/mL), respectively. Compound 3 was also cytotoxic to several cancer cell lines in vitro as potent as the activities of Iissoclibadins 1 and 2. Compounds 4 and 5 reduced the cell proliferation of L1210 to 60% of a control at 20.0μM (9μg/mL).
2007-08-24

P-41 群体ボヤLissoclinum cf. badiumから単離した新規Lissoclibadin類(ポスター発表の部)

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