P-75 Fusarielin Aの生物活性とその分子基盤(ポスター発表の部)

概要

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A new antifungal antibiotic, fusarielin A (FSA), was obtained from a culture of a Fusarium sp. K432. FSA induced curling on mycelia germinated from conidia of Pyricularia oryzae P-2b. This biological feature was utilized as a screening assay for compounds that interfere with microtubule function, such as rhizoxin, griseofulvin and nocodazole. So we have speculated that this feature was caused by the inhibition of the assembly of microtubule protein. But FSA had no inhibitory activity to the assembly or disassembly of microtubule protein prepared from porcine brain. Recently, it was reported that ICM0301A, whose structure is similar to FSA, inhibited the growth of a human umbilical vein endothelial cell (HUVEC) and showed significant anti-angiogenic activity. Based on the results, we expected that FSA would show the inhibitory activity to angiogenesis. In fact, FSA showed anti-angiogenic activity. Our purpose of the,research is to reveal the target molecule of FSA and the molecular mechanism of anti-angiogenic activity elicited by FSA.
天然有機化合物討論会の論文
2007-08-24