NITRIC OXIDE PRODUCTION IN MOUSE PERITONEAL MACROPHAGES ENHANCED WITH GLYCYRRHIZIN
スポンサーリンク
概要
- 論文の詳細を見る
The enhancement of nitric oxide (NO) production in glycyrrhizin (GL)-induced macrophages (Mφ) in response to lipopolysaccharide (LPS) was investigated. NO production in GL-induced macrophage culture supernatants was stimulated in response to LPS (10 μg/ml) for 24-or 48-h cultures, and these levels were compared three times with the levels in saline-induced peritoneal exudate cell cultures. Furthermore, Mφ induced with proteose peptone (PP) containing GL could generate greater NO production than Mφ induced with PP alone. However, no stimulation of NO production was observed by addition of GL in the cultures of Mφ induced with thioglycollate or Bacillus Calmette Guerin. Moreover, GL-induced Mφ showed cytostasis against such tumor target cells as L 1210 and P 388 lymphoma cell lines. These observations indicate that GL can activate the Mφ in vivo system and stimulate NO production in response to LPS.
- 公益社団法人日本薬学会の論文
- 1994-05-15
著者
-
近藤 嘉和
Pharmaceutical Inst Institute, Tohoku University
-
高野 文英
東北大学薬学部附属薬用植物園
-
近藤 嘉和
Pharmaceutical Institute Tohoku University
-
近藤 嘉和
東北大学薬学部
-
高野 文英
Pharmaceutical Institute, Tohoku University
-
高野 文英
東北大学 薬
-
高野 文英
Pharmaceutical Institute Tohoku University
関連論文
- Studies on the Constituents of Cimicifuga spp. XIII. Structure of Cimicifugoside
- オウバクより単離された γ-Hydroxybutenolide 誘導体と Limonoid の光酸化反応
- Long-range Effect of Halogen in the Nuclear Magnetic Resonance Spectra of Halosteroids
- INHIBITORY EFFECT OF BISBENZYLISOQUINOLINE ALKALOIDS ON THE QUICK DEATH OF MICE TREATED WITH BCG/LPS
- タンニン及び数種の関連化合物のラットのエタノ-ル胃損傷に対する効果
- イヌガンソクの成分研究 新フラバノンMatteucinおよびMethoxymatteucinの構造
- Studies on the Constituents of Chloranthus spp. III. Six Sesquiterpenes from Chloranthus japonicus
- Studies on Constituents of Iris Genus Plants. III. The Constituents of Iris florentina L. (1)
- Studies on Shikon. III. New Furylhydroquinone Derivatives, Shikonofurans A, B, C, D and E, from Lithospermum erythrorhizon SIEB. et ZUCC.
- 川蜀七根の成分研究(第2報)スピロスタン系化合物の単離と構造研究
- 川蜀七根の成分研究(第1報)スピロスタン系サボゲニンの単離と構造研究
- Spasmolytic Substances from Cimicifuga dahurica MAXIM.
- Selective Chemical Alkylation of Nucleotides with Triethyloxonium Fluoroborate
- Protoberberine型アルカロイドの反応(第10報)Acetoneberberine-KMnO_4酸化生成物の構造 その2
- A Photoreductive Removal of the Toluene-p-sulfonyl Group
- 続随子の成分研究(第5報)種子油の成分について
- 続随子の成分研究(第4報)Ester L_3の構造について
- コレステロール構造類似のACAT阻害剤
- NITRIC OXIDE PRODUCTION IN MOUSE PERITONEAL MACROPHAGES ENHANCED WITH GLYCYRRHIZIN
- Iris属植物の成分研究(第6報)ニオイイリスIris florentina L.の根茎成分とシャガIris japonica THUNB.の花弁成分
- Proton Magnetic Resonance Study of Some 17-Substituted Steroids
- Application of the Infinite Dilution Shifts in Acid-Base System to Organic Chemistry. I.Relation between the Infinite Dilution Shifts of Monosubstituted Benzoic Acids in Pyridine and the Hammett δ Values
- Oxindoles(第5報)オキシインドール-スピロ二量体の選択的ソルボリシス
- Isolation of Ovulatory-Active Substances from Crops of Job's Tears (Coix lacryma-jobi L. var. ma-yuen STAPF.)
- ベルベリン熱分解物Berberrubineによる腫瘍細胞の増殖抑制
- Studies on the Constituents of Vitex rotundifolia L. fil.
- 数種のBerberinium塩の腸内常在菌に対する抗菌作用
- 続随子の成分研究(第1報)Epoxylathyrolの単離と反応
- Synthesis of 5-Pyrazolylbarbituric Acid Derivatives
- ベルベリン熱分解物berberrubineによる腫瘍細胞の増殖抑制
- A New Diglyceride from Root-Barks of Morus alba L.
- The Structure of a New β-Carboline Alkaloid from Picrasma ailanthoides PLANCHON
- Reactions of Protoberberine-Type Alkaloids. IX. The Structure of a KMnO_4 Oxidation Product of Acetoneberberine. (I)
- The Structure of Cimifugin, a New Bitter Principle from Cimicifuga simplex WORMSK.
- 秦〓の成分研究
- 紫根の研究 : 硬紫根より得られた無色結晶
- 数種のBerberinium塩の腸内常在菌に対する抗菌作用