Steroidal Inhibitors of Microbial Degradation of Sterol Side Chains
スポンサーリンク
概要
- 論文の詳細を見る
Methyl esters of acetylene carboxylic acids (2 and 3), an α-bromo acid (4), and α, α-difluoro acids (5 and 6) were synthesized as analogues of the C-24 carboxylic acid which is an intermediate in the microbial degradation of sterol side chains, and these compounds were shown to be inhibitors of the degradation reaction.
- 公益社団法人日本薬学会の論文
- 1986-07-25
著者
-
大塚 幹夫
Department Of Chemistry Tokyo Institute Of Technology
-
池川 信夫
新潟薬科大学
-
池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
-
藤本 善徳
Department of Chemistry, Tokyo Institute of Technology
-
藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
関連論文
- NON-STEREOSPECIFIC FORMATION OF 3α, 7α, 24-TRIHYDROXY-5β-CHOLESTAN-26-OIC ACID DURING CHENODEOXYCHOLIC ACID BIOSYNTHESIS
- Non-stereoselective Formation of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid during Cholic Acid Biosynthesis
- Stereochemistry of Hydrogen Addition to C-25 of Desmosterol by Sterol-Δ^-Reductase of Rat Liver Homogenate
- IDENTIFICATION OF 27-NOR-3α, 7α, 12α-TRIHYDROXYCOPROSTAN-24-ONE APPARENTLY DERIVED FROM 3α, 7α, 12α-TRIHYDROXY-24-OXOCOPROSTANOIC ACID, A POSTULATED INTERMEDIATE OF BILE ACID BIOSYNTHESIS
- Synthesis of 26,27-Dialkyl Analogues of 1α, 25-Dihydroxyvitamin D_3
- SYNTHESIS OF 1_α, 25-DIHYDROXY-26,27-DIMETHYLVITAMIN D_3,A HIGHLY ACTIVE ANALOGUE OF 1_α, 25-DIHYDROXYVITAMIN D_3
- Formation of 9,25-Cyclofernane by Reductive Homoallylic Cyclization of Fern-9(11)-en-25-ol Mesylate
- Annonaceous Acetogenins from the Seeds of Annona squamosa.Adjacent Bis-tetrahydrofuranic Acetogenins
- A NOVEL STEROIDAL SAPOGENIN, POGOSTEROL FROM VERNONIA POGOSPERMA
- Synthesis of Some Side-Chain Homologues of 1α, 25-Dihydroxyvitamin D_3 and Investigation of Their Biological Activities
- Synthesis and Biological Activity of 1α-Hydroxy-24,24-dimethyl-22E-dehydrovitamin D_3 and 1α, 25-Dihydroxy-24,24-dimethyl-22E-dehydrovitamin D_3
- Synthesis and Biological Activity of (22E, 24R)- and (22E, 24S)-1α, 24-Dihydroxy-22-dehydrovitamin D_3
- Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
- Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
- 功労賞受賞 Masato Tanabe氏の業績
- 植物ステロール側鎖の生合成機構の精密解析
- 津田恭介先生の研究業績
- 津田恭介先生を偲ぶ
- 微量分析30年 : 池川信夫先生にきく
- 薬学会賞受賞 岩崎成夫氏の業績
- 故 岩井一成先生を偲んで
- 大腸がんとビタミンD : 含フッ素1,25-(OH)_2D_3アナログDD-003のin vivo実験
- Fatty Acids and Sterols of the Tunicate, Salpa thompsoni, from the Antarctic Ocean : Chemical Composition and Hemolytic Activity
- Structure of Acrosome Reaction-Inducing Steroidal Saponins from the Egg Jelly of the Starfish, Asterias amurensis(Organic,Chemical)
- 26,27-DIETHYL-1α,25-DIHYDROXYVITAMIN D_3 AND 24,24-DIFLUORO-24-HOMO-1α,25-DIHYDROXYVITAMIN D_3 : HIGHLY POTENT INDUCER FOR DIFFERENTIATION OF HUMAN LEUKEMIA CELLS HL-60(Communications to the Editor)
- Synthesis of 28-Norbrassinolides and Related 2-Deoxysteroids(Organic,Chemical)
- Synthesis of 5α-Cholestan-6-one Derivatives with Some Substituents at the C-1, C-2, or C-3 Position(Organic,Chemical)
- Structure-Activity Relationship of Brassinosteroids with Respect to the A/B-Ring Functional Groups(Organic,Chemical)
- Synthesis of Deuterio-Labelled Brassinosteroids, [26,28-^2H_6]Brassinolide, [26,28-^2H_6]Castasterone, [26,28-^2H_6]Typhasterol, and [26,28-^2H_6]Teasterone
- Synthesis of 3β, 6α-Dihydroxycholesta-9(11), 17(20), 24-trien-23-one, the Aglycone of Acrosome Reaction-Inducing Steroidal Saponin Co-ARIS II
- Synthesis of a New Amino Acid-Antibiotic, Oxetin and Its Three Stereoisomers
- 80 昆虫におけるシトステロール側鎖切断反応の中間体フコステロールエポキシドについて
- SYNTHESIS OF β-OXO THIOL ESTERS RELATED TO BILE ACID BIOSYNTHESIS
- Identification of the Aglycon Part of Vineomycin A_1 with Aquayamycin
- 75 セトミマイシンの構造と生合成
- Studies on Steroids. LXIII. Synthesis of Cholesterol Analogs with a Modified Side Chain
- Carbon-13 Nuclear Magnetic Resonance of 24-Substituted Steroids
- Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
- 54(P1-2) フコステロールエポキシドの酵素的、化学的転位反応のメカニズム(ポスター発表の部)
- Synthesis of Demethylgorgosterol and Its Stereoisomers
- Studies on Steroids. XLV. Synthesis of the Four Stereoisomers of 20,22-Dihydroxycholesterol
- 41 Cholesterolの側鎖切断反応について
- Identification of 24-Epibrassinolide in Bee Pollen of the Broad Bean, Vicia faba L.
- 活性型ビタミンD (動的天然物化学)
- Angiotensin Converting Enzyme-Inhibitory Triterpenes from Ganoderma lucidim
- Steroidal Inhibitors of Microbial Degradation of Sterol Side Chains
- Stereochemistry in the Hydrogenation of Steroidal(22R)- and (22S)-Δ^-26,22-Lactones
- Pyridine-Induced Deshielding of 4-Methylene Protons for the Determination of C-6 Stereochemistry of Sterols Having a 5α, 6-Diol Moiety. Revision of the C-6 Stereochemistry of Marine Sterol Isolated from a Sponge, Dysidea sp.
- Side Chain Structural Requirement for Utilization of Sterols by the Silkworm for Growth and Development. Non-stereoselective Utilization of the 24-Stereoisomeric Pairs of 24-Alkylsterols
- EFFECTIVE SEPARATION OF STEROL C-24 EPIMERS BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
- 51 Gorgosterolの立体選択的合成
- ステロイド生合成における炭素-炭素結合の切断反応-2-側鎖部における反応について
- ステロイド生合成における炭素-炭素結合の切断反応-1-ステロイドホルモンの生合成について
- Hydrogenolysis of Allylic Alcohols with Mixed Hydride Reagent of Lithium Aluminum Hydride-Titanium Tetrachloride
- OXYGENATED STEROLS AS INHIBITORS OF ENZYMATIC CONVERSION OF DIHYDROLANOSTEROL INTO CHOLESTEROL
- Effects of Cholesterol Analogs on Cholesterol Biosynthesis from Lanosterol
- Synthesis of 1α-Fluorovitamin D_3
- Squamosten-A, a Novel Mono-tetrahydrofuranic Acetogenin with a Double Bond in the Hydrocarbon Chain, from Annona squamosa L.
- Synthesis and Activity of B-Ring Modified Brassinosteroids
- Annonaceous Acetogenins from the Seeds of Annona squamosa.Non-adjacent Bis-tetrahydrofuranic Acetogenins
- 27 Withanolidesの合成研究
- Non-stereoselective Conversion of the Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid into Cholic Acid
- Analysis of 2-Deoxybrassinosteroids by Gas Chromatography-Mass Spectrometry
- SYNTHESIS OF [26,28-^2H_6]BRASSINOLIDE, [26,28-^2H_6]CASTASTERONE, [26,28-^2H_6]TYPHASTEROL, AND [26,28-^2H_6]TEASTERONE
- Short-Step Synthesis of Plant Growth-Promoting Brassinosteroids
- Synthesis of (22R, 23R)-28-Homobrassinolide
- Squamocin, a New Cytotoxic Bis-tetrahydrofuran Containing Acetogenin from Annona squamosa
- 23-Hydroxyphysalolactone, a New Withanolide with a 23-Hydroxyl Group from Physalis peruviana (Solanaceae)
- 46 古細菌細胞膜脂質の生合成機構(口頭発表の部)
- Synthesis and Determination of Stereochemistry of Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid
- Biological Properties of 20-Isocholesterol
- Configuration at the C-23 Position of 23-Hydroxy- and 23,25-Dihydroxycholesterols
- Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
- Synthesis of Active Forms of Vitamin D. IV. Synthesis of 24,25- and 25,26-Dihydroxycholesterols
- 活性型ビタミンD
- Preparation of (26-^C)Desmosterol
- PHOTOCHEMICAL REACTION OF CHOLESTEROL ANALOGS WITH A CARBENE-GENERATING SUBSTITUMENT ON THE SIDE CHAIN
- SYNTHESES OF CHOLESTEROL ANALOGS WITH A CARBENE-GENERATING SUBSTITUENT ON THE SIDE CHAIN
- Synthesis of Active Forms of Vitamin D. X. Synthesis of 1α-Hydroxyvitamin D_3
- Synthesis of Active Forms of Vitamin D. III. Synthesis of 1α, 25-Dihydroxycholesterol
- Free Sterols of the Sea Urchin Echinometra lucunter
- Oxygenated Sterol Derivatives. Their Identification from the Fungus-Infected Silkworm Carcass, Bombyx cum Botryte, and Their Effects on Growth and Sterol Metabolism of the Silkworm, Bombyx mori
- Nutritional Effect of Some Cholestenols and Cholestadienols on the Silkworm Bombyx mori
- High Pressure Liquid Chromatography of Sterol Benzoates
- 昆虫におけるステロイド代謝
- Studies on Steroids. XXXIX. Sterol Profiles of Red Algae. (2)
- Studies on Steroids. XXXVIII. A New Preparation of 1α-Hydroxycholesterol
- 2.活性型ビタミンD_3群の合成について(紹介講演)(脂溶性ビタミン総合研究委員会 : 第155回会議研究発表要旨)
- Synthesis of Homodolichosterone and Related 2-Deoxysteroids(Organic,Chemical)