Non-stereoselective Formation of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid during Cholic Acid Biosynthesis
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概要
- 論文の詳細を見る
Incubation of (25RS)-, (25R)- and (25S)-3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA, 6,6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10,11) were also converted non-stereoselectively to a 1 : 1 mixture of the epimeric 24-hydroxy compounds (12).
- 社団法人日本薬学会の論文
- 1994-05-15
著者
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小林 典子
共立薬大
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森崎 益雄
共立薬大
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由利 正利
東工大・理
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萩原 千秋
共立薬大
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小林 典子
Kyoritsu College of Pharmacy
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萩原 千秋
Kyoritsu College of Pharmacy
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森崎 益雄
Kyoritsu College of Pharmacy
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由利 正利
Department of Chemistry, Tokyo Institute of Technology
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藤本 善徳
Department of Chemistry, Tokyo Institute of Technology
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大谷 いずみ
Department of Chemistry, Tokyo Institute of Technology
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藤本 善徳
東工大院理工
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藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
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大谷 いずみ
Department Of Chemistry Tokyo Institute Of Technology
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